Ankylosing Spondylitis (AS)
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Ankylosing Spondylitis (AS)
Ankylosing spondylitis (AS) is an inflammatory autoimmune disease that, over time, can cause some of the small bones in the spine (vertebrae) to fuse. This fusing makes the spine less flexible and can result in a hunched-forward posture. AS affects men more often than women. Signs and symptoms typically begin in early adulthood (15–30 years old) and an estimated 300,000 Canadians have AS. AS has no known specific cause, though genetic factors seem to be involved.
ABRILADA is used to treat adults with ankylosing spondylitis (AS).
Your immune system works to protect your body from bacteria, viruses, and other foreign agents. In AS, the immune system mistakenly recognizes the body as foreign and attacks healthy body cells.
When you have AS, your immune system overproduces a substance called TNF-alpha (which stands for tumour necrosis factor alpha). The extra TNF-alpha can attack normal healthy body tissues and cause inflammation, especially in the bones, cartilage and joints.
The way ABRILADA works is by binding to TNF-alpha and decreasing the inflammation process of AS. However, ABRILADA can also lower the body’s ability to fight infections, and taking it can make you more prone to getting infections, or make any infection worse.
ABRILADA is administered by injection under the skin, also called a subcutaneous injection.
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